Clyde, Bess, Victor, Lizzy, and Kris are college students, waiting for a late substitute to arrive so that class can begin. But unbeknownst to them, Dr. Doe has other plans for them. Posing as their substitute teacher she enters their classroom and secretly infects Clyde with her experimental formulae. This is the first domino to fall in a sequence of bizarre events that hour.
Dr. Doe explains that these changes are brought about by any type of physical contact, watching the second student turn into moaning, needing bovine. One by one the other students meet a similar fate, each turning into their own spirit animal.